• br Conclusion br Conflict of interest br

  2023-04-14

  

  Conclusion Conflict of interest Acknowledgements Introduction Human salivary aldehyde dehydrogenase (hsALDH) (E.C. 1.2.1.5) is the first line of defence against toxic aldehydes in the oral cavity. HsALDH is primarily a dimeric, class 3 ALDH (ALDH3A1) specific for aromatic and long/medium

• Ketogenic diets are more effective

  2023-04-14

  

  Ketogenic diets are more effective in promoting weight loss than conventional caloric restriction [26] however, their effect on hepatic glucose and lipid metabolism remains inconclusive. Blood glucose homeostasis is tightly regulated. In both mice and humans consuming KD, baseline blood glucose decr

• Whether similar mechanisms play a role in adiponectin signal

  2023-04-14

  

  Whether similar mechanisms play a role in adiponectin signal transduction and whether additional proteins are recruited to adiponectin receptors via APPL1 has not been analysed so far. Although it has been clearly established that APPL1 is a downstream adaptor protein in adiponectin signal transduct

• The subdivision of HT receptors started in

  2023-04-14

  

  The subdivision of 5-HT receptors started in the 1950s by Gaddum and colleagues, when they realised that in the guinea pig ileum, the effects of 5-HT could be blocked in part by morphine (M), and in part by dibenzyline (D). Gaddum and Picarelli proposed two receptor classes, 5-HT M and 5-HT D (1957)

• Introduction Myasthenia gravis MG is an autoimmune

  2023-04-14

  

  Introduction Myasthenia gravis (MG) is an autoimmune disorder characterized by muscle weakness, which is mainly due to autoantibodies reducing the number or function of postsynaptic Fosmidomycin sodium salt receptors (AChRs) [1], [2]. Animal models have been developed to uncover the immunopathogen

• In summary we could identify and experimentally confirm two

  2023-04-14

  

  In summary, we could identify and experimentally confirm two novel SBEs within the 5-LO promoter and we were able to demonstrate that TGFβ and SMADs stimulate 5-LO promoter activity. Moreover, an elevated 5-LO expression has been linked to different forms of leukaemia. Therefore, the influence of ML

• The extent to which GPCR oligomerization is

  2023-04-14

  

  The extent to which GPCR oligomerization is a regulated process still remains unclear. Reported effects of ligands on both GPCR homo- and heteromers are highly variable and depend on GPCR subtypes and the specific ligand used. According to our data, chronic treatment of mice with both paroxetine or

• Fig A shows a schematic representation of histological resul

  2023-04-14

  

  Fig. 2A shows a schematic representation of histological results according to the Franklin and Paxinos Mouse Brain Atlas (2001). The black circles represent the sites of drug infusion that were on-target within the amygdala. Gray circles represent the animals that had infusion locations outside the

• NOXA a BH only protein is

  2023-04-14

  

  NOXA, a BH3-only protein, is best known as a selective inhibitor of MCL-1, which is a highly expressed pro-survival protein in many human malignancies [30]. In addition, NOXA was recently proven to act as a direct activator via directly binding to BAX to induce apoptosis [31]. Given that its levels

• In the nineties we knew that

  2023-04-14

  

  In the nineties we knew that (-)baclofen was the stereo-selective ligand for the GABAB receptor which had been recognised by Norman Bowery as a receptor for GABA, which was different from the GABAA receptor (Hill and Bowery, 1981). GABAB receptor antagonists were also synthesised and made available

• br Aromatase inhibitors The aromatase enzyme P arom belongs

  2023-04-14

  

  Aromatase inhibitors The aromatase enzyme, P450arom, belongs to the super-family of P450 proteins which includes more than 480 members divided in 74 different families. P450arom is a unique member of family 19 [39], and is located in the endoplasmic reticulum of mammalian Kobe0065 that express t

• On the other hand our study permits to draw

  2023-04-14

  

  On the other hand, our study permits to draw general conclusions about the complex functional pattern of C4HT, C8HT and C12HT, in comparison with the parent molecule HT and two reference compounds like Trolox and vitamin E. Table 1 summarizes the results obtained in the present investigation (for th

• Androgen receptor translocates from the cytoplasm to the

  2023-04-13

  

  Androgen receptor translocates from the cytoplasm to the nucleus after binding to its ligands (Quigley et al., 1995). In the current study, although propofol did not significantly affect total androgen receptor protein levels, it significantly decreased nuclear androgen receptor levels. These findin

• br Acknowledgments and Disclosures br Alzheimer s disease as

  2023-04-13

  

  Acknowledgments and Disclosures Alzheimer's disease as a synaptic pathology Alzheimer's disease (AD) is a chronic neurodegenerative NMS-E973 disorder and the most common cause of dementia in the elderly. Progressive depositions of amyloid plaques and neurofibrillary tangles together with degen

• br Conclusion P gingivalis expresses various exopeptidases i

  2023-04-13

  

  Conclusion P. gingivalis expresses various exopeptidases, i.e., DPP4, DPP5, DPP7, DPP11, PtpA, and AOP, in periplasmic space, which produce di- and tri-peptides from most oligopeptides. This oligopeptide processing step is important as an extracellular event in the 745 of asaccharolytic P. gingi

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